Can one campaign destroy domain trust?

Possible. One severely problematic campaign (sending to purchased list, massive trap hits, extreme complaints) can cause significant reputation damage. Recovery takes sustained good behavior over time.

Single normal campaigns rarely destroy trust. Unusual disasters like sending to an entirely purchased list or compromised account can cause immediate severe damage.

Protect against catastrophic campaigns through list hygiene, consent verification, and approval processes. One mistake can take months to recover from.